603 papers
This study reveals that the splicing activator U2AF2 promotes intron retention in lncRNAs PURPL and MALAT1, a mechanism essential for their nuclear localization and the subsequent regulation of cell proliferation and migration.
The paper introduces SCALE, a scalable foundation model for virtual cell perturbation prediction that integrates a high-throughput BioNeMo framework, a stable conditional transport architecture with LLaMA-based encoding, and biologically faithful evaluation metrics to overcome existing bottlenecks in efficiency, stability, and biological fidelity.
This study reveals that in *C. elegans*, selective activation of the IRE-1/XBP-1 branch of the unfolded protein response, while suppressing the PEK-1 branch, coordinates enhanced protein folding with restored translation machinery to drive rapid organismal rejuvenation from adult reproductive diapause upon refeeding.
This study demonstrates that RNF43 does not directly regulate endogenous EGFR or BRAF protein stability, revealing that previously observed EGFR elevation in certain knockout models was an artifact of CRISPR/Cas9 vector integration rather than a genuine biological effect.
This study demonstrates that the abundance of non-translated mRNA dictates the assembly pathway and biophysical properties of cytoplasmic processing bodies (P-bodies), where strong translation attenuation leads to the formation of few, bright, and fluid P-bodies that recruit decay factors en bloc, while weaker attenuation results in numerous, dim, and viscous P-bodies with sequential protein recruitment.
Using human iPSC-derived cortical neurons, this study reveals that while both ST3GAL5 and B4GALNT1 deficiencies eliminate major gangliosides, only ST3GAL5 loss triggers a fatal reprogramming of the lipid repertoire that depletes plasma membrane proteins and abolishes neuronal activity, whereas B4GALNT1 deficiency is compensated by precursor sialylated lipids that preserve membrane organization and electrical function.
This study introduces a novel competitive transplantation assay in humanized NBSGW mice using HLA-mismatched CD34+ cells to enable simultaneous engraftment and longitudinal tracking of distinct human grafts, thereby filling a critical translational gap for assessing intrinsic repopulating capacity and advancing human hematopoietic biology.
This study establishes a live-cell autophagy reporter in naked mole-rat skin fibroblasts to reveal that, unlike conventional models, these cells exhibit a distinct steady-state autophagy-lysosome organization and undergo a unique, reversible vacuolation response to lysosomal stress without acute cytotoxicity.
This study identifies Cep192 insufficiency as the primary cause of haploid instability in human cells due to failed spindle bipolarization and demonstrates that restoring Cep192 levels, particularly in combination with enhancing the acentrosomal spindle pathway, effectively stabilizes the haploid state for genome engineering applications.
This study demonstrates that the inner nuclear membrane protein Sun2 acts as a critical mechanosensing node required for stiffness-dependent extracellular matrix production and lung fibrosis, suggesting that targeting Sun2-containing LINC complexes could mitigate fibrotic disease.