415 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study identifies a rare Tcf4 lineage-negative stem cell population in the colon that is essential for wound repair and serves as the specific cell of origin for Apc-deletion-induced tumors in a Tcf4-haploinsufficient background.
This study reveals that C9ORF72-derived polyGR polypeptides disrupt nucleocytoplasmic transport in ALS/FTD by non-linearly retuning the nuclear pore's selectivity barrier, causing a biphasic modulation where proteins with moderate hydrophobicity exhibit enhanced transport while highly hydrophobic proteins are suppressed and accumulate in the cytoplasm.
This study reveals that TRIM21 functions as a molecular rheostat for influenza A virus replication by exerting expression-dependent, graded effects that couple viral nucleoprotein ubiquitination with innate immune modulation, while simultaneously restraining a latent PRKDC-mediated antiviral pathway.
This study identifies SLC33A1 as the primary transporter responsible for exporting oxidized glutathione (GSSG) from the endoplasmic reticulum, a critical mechanism for maintaining ER redox homeostasis and ensuring proper protein maturation.
The paper introduces the Advanced Mobile Laboratory (AML), a field-deployable platform that integrates high-end imaging, cell sorting, and cryo-preparation technologies to enable immediate, multiscale analysis of environmental microbial communities directly at the sampling site, thereby bridging the gap between field ecology and mechanistic cell biology.
This study demonstrates that the FDA-approved PPARγ agonist rosiglitazone effectively redirects fibro-adipogenic progenitors from forming ectopic bone to generating ectopic fat, thereby eliminating heterotopic ossification lesions in mouse models of both fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification.
This study reveals that immune cell directional persistence in complex 3D environments is stabilized not by the abundance of protrusions, but by the temporal organization of protrusion dynamics coordinated by two spatially distinct myosin II architectures at the leading edge and rear.
This study identifies Msc1 as a glucose starvation-responsive regulator that accumulates at the nucleus-vacuole junction to drive its functional maturation and facilitate associated stress-responsive transcriptional programs in yeast.
This study demonstrates that aberrant activation of the AURKA/HDAC6 axis drives primary cilia shortening and fibroblast activation in Systemic Sclerosis, identifying AURKA as a promising therapeutic target to reverse the fibrotic phenotype.
The study demonstrates that the intrinsically disordered region of the Drosophila protein Zasp52, which is specifically expressed in indirect flight muscles, is essential for anchoring thin filaments to the Z-disc and maintaining sarcomere integrity during contraction.